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High Fat Diet May Elevate Colon Cancer Risks

Colorectal cancer is widespread in people across the world. The colon is an organ that plays a significant role in the body’s digestive system. It helps to process and supply nutrients to the body. Colorectal cancer symptoms may go unnoticed in early stages; that is why it is recommended for people to start screening at the age of 50 or 40 for those at high risk.

A lot of people are at high risk of developing colorectal cancer due to dietary and other factors. Incidences of the disease are high in some parts of the world and low in others. People who are obese, smokers, elderly are of African descent, and have a family history or consume high amounts of alcohol are prone to colorectal cancer risks.

Studies indicate that a diet high in fats can increase the risks of the disease. Scientists have found a connection in the way body cells consume fate and how genes regulate the behavior of stem cells in intestines.

According to a study;

  • The two genes that help stem cells to burn fats in the body have a role in colon cancer risk. They include the HNF4A and HNF4G genes, which work to ensure that the intestinal lining is functioning correctly.
  • Too much fat in the intestines can increase the number of stem cells and boost an individual’s risk of colon cancer.
  • The stem cells in the intestines get renewed constantly to help fuel the regeneration of the intestinal lining. Any alteration in the function of the stem cells can cause colon cancer.
  • When the genes are inactivated, the intestinal stem cells are likely to malfunction, causing the intestines to stop burning fat.

In conclusion, it was observed that the two genes could help the stem cells to burn fat and generate energy as well. However, more studies are required in order to determine if these genes can alter the cancer risk and the stem cell numbers when one consumes a high-fat diet.

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